2-Aminobenzoxazole ligands of the hepatitis C virus internal ribosome entry site.
نویسندگان
چکیده
2-Aminobenzoxazoles have been synthesized as ligands for the hepatitis C virus (HCV) internal ribosome entry site (IRES) RNA. The compounds were designed to explore the less basic benzoxazole system as a replacement for the core scaffold in previously discovered benzimidazole viral translation inhibitors. Structure-activity relationships in the target binding of substituted benzoxazole ligands were investigated.
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ورودعنوان ژورنال:
- Bioorganic & medicinal chemistry letters
دوره 24 15 شماره
صفحات -
تاریخ انتشار 2014